The new clinic is part of private service Gender Plus, which offers young people questioning their gender identity psychological support for a fee.
On its website, the CQC says new services are checked to ensure they are “safe, effective, caring, responsive, and well led”.
The approval means Gender Plus, which has offices in London, Birmingham and Dublin, will be able to prescribe hormones to over-16s in the UK who have been assessed by a team of clinical psychologists across a minimum of six sessions.
Not all patients will be suitable for hormones, clinicians say, and the clinic will not prescribe puberty-blocking treatment.